Rheumafort - Possible Mode of Action

Rheumafort provides 6 plant extracts. Each of these extracts provides whole complex, many times dozen or so different active compounds. Due to the such complex composition of Rheumafort and on the basis of several in vitro studies and on the basis of the data from literature regarding the possible mode of action of the active compounds, one can anticipate that Rheumafort has also very complex mechanism of action.

It is suggested that Rheumafort i. a. may inhibit two key enzymes: cyclooxygenase II (COX-2) and 5-lipooxygenase (5-LOX). These two enzymes are responsible for formation of several molecules that lay in background of inflammation symptoms. Cyclooxygense converts arachidonic acid into so called prostaglandings cascade. 5-lipooxygenase pathway is the major source of potent proinflammatory leukotrienes issued from the metabolism of arachidonic acid, long acting chemical sustances responsible for pain and inflammation.

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Immune system plays key role in the pathogenesis of several inflammatory rheumatic diseases. Due to its pathologic agitation it comes to involvement of the connective tissue, which is resulting in inflammatory process with participation of different cells of this tissue. These cells release several cytokines that play key role in initiating and continuation of inflammation. Depending on character of disease inflammation may be accompanied by destructive or proliferative processes, which in case of rheumatic diseases are located in joint and surrounding tissue.

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Please notice! The presented product is a dietary supplement and this presentation does not intend to attribute to it the property of preventing, treating or curing any human disease, or refer to such properties. Exact to Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002.