Spirulina Platensis Extract vs Cold Sore Virus - 2

Lars Lindmark i Michelle Schøring-Thyssen

Effect of Spirulina Platensis Extract supplementation on recurrent Herpes simplex (HSV-1) cold sores

herpes treatment

Cold sores, around the mouth, with painful blisters are very common condition caused by the herpes simplex virus (HSV-1). Weakness of immune system due to sever cold infection, stress, UV exposure and/or fever is believed to play an important role in the reactivation of the virus and return of blisters. No good treatment is available.

Aim of study

ImmuMax and Immulina are unique commercial microalgae extract from Arthrospira platensis with proven immunostimulotory and modulatory properties. Anecdotal evidence suggest that this microalgae extract could be a valuable supplement to alleviate symptoms of cold sore.

Subjects and Methods

A double-blind placebo controlled, trial of an oral microalgae extract for the prevention and treatment of recurrent herpes simplex (HSV-1) infection was conducted to evaluate usefulness and efficacy. The critical inclusion criterion was more than 6 episodes of cold sores (oral herpes) during past 12 months.

The active group was given Spirulina Extract capsules (400 mg per day) for 16 weeks. The placebo capsules contained microcrystalline cellulose. The study was conducted as consumer study, where the participants kept continuous daily diary of symptoms. A total number of 148 participants (age 18 - 65) entered the trial of which 84 (22 males and 62 females) subjects on active treatment and 64 (18 males and 46 females) subjects on placebo completed the trial.


The Spirulina Extract treatment group had an average of 40% less HSV infections during the whole testing period. Number of total symptom free participants during the whole study was 34/84 (40 %) for Spirulina Extract compared 4/64 (6 %) with the placebo (p˂0.02). During last 8 weeks of the study the non-recurrence evidence was 51/84 (61 %) and 16/64 (25 %) for the active and placebo group respectively. This means that in the active Spirulina Extract group 58 % more cases were without cold sores as compared to the placebo group.

The statistical analysis (Fisher-Snedecor Exact Test) show a significance with p˂0.02. No side effects were reported. There is also a tendency that males might respond better than females.

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Spirulina Extract versus virus infection (pdf 9 pages)


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