Yeast derived 1,3-1,6-β-D-glucan is active ingredient of ImmuMax
ImmuMax - Composition and Mode of Action - 3

Bakers’ yeast as well brewers’ yeast has a long history of safe consumption. It has been used for over a thousand of years in the production of bread, wine, and beer. Although allergies to Sacharomyces cerevisiae from food consumption might occur, they are rare. In general, yeast products are very well tolerated. Yeast is rich source of beta-glucans.

Beta-glucan are derived from two main vegetable sources:
• cereal derived (oat, rye, barley, etc) soluble β-glucans and
• mushroom derived (yeast, shiitake, schizophyllum, reishi, etc) insoluble β-glucans

The first group has short glycosidic chains bonds at β 1→3 and 1→4 position and it is water soluble. This group of beta-glucans reveals strong metabolic activty reducing elevated suger and lipid blood level (cholesterol).
The second group has long glycosidic chains combined bonds at β 1→3 position and short lateral chains at 1→6 position. It is water insoluble. This group reveals immune system effective stimulating properties.

Uptake of β-glucans has been shown in mice with soluble and particulate yeast (1,3)-(1,6)-glucans labeled with fluorescein. Both types of yeast β-1,3-glucans were taken up by gastrointestinal macrophages, and then processed forms were transported to the lymph nodes, spleen and bone marrow. Also, in vitro experiments have shown that β-glucans were degraded inside macrophages and released into the culture medium, which makes them eventually available for the circulating system and a systemic distribution.

Orally administered β-glucans induced phagocytic activity, oxidative bursts, and IL-1 production of peritoneal macrophages in mice. A higher phagocytic activity and oxidative metabolism of neutrophils and monocytes, indicating an immune restoring activity of yeast β-glucan has also been shown in rats. However, not only the cellular but also the humoral acute phase immune reaction is affected by yeast β-glucan feeding as shown by increased lysozyme and ceruloplasmin activitiy.

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Please notice! The presented product is a dietary supplement and this presentation does not intend to attribute to it the property of preventing, treating or curing any human disease, or does not refer to such properties. Exact to the Directive 2002/46/EC of the European Parliament and of the Council on 10 June 2002.