LCEPEEN - Spirulina Platensis Extract
is an active ingredient of Immulina and ImmuMax
ImmuMax - Composition and Mode of Action - 2

The Special Extract from Spirulina Platensis has been marked by the manufacturer a "LCEPEEN" registered code name. LCEPEEN is received in patented extraction process. LCEPEEN Extract is a novel immunomodulator derived from Spirulina platensis (Arthrospira), a member of the blue-green algae family (Cyanobacteria) . Preparations of Spirulina are popular dietary supplements that are consumed for their high nutritional value and their immunostimulatory properties. LCEPEEN Extract is a patented aqueous alcohol extract of Spirulina containing high molecular weight polysaccharides. This preparation has been identified as a potent activator of cells of the immune system. In tissue culture, LCEPEEN Extract stimulates cells of the monocyte-macrophage system and dendritic cells to produce regulatory "pro-inflammatory" cytokines. In mice, LCEPEEN Extract is 10 times more efficacious than Spirulina in stimulating immune cells. In human monocytic THP-1 cells, this stimulatory effect of LCEPEEN Extract can be traced to the activation of NF-κB, a transcription factor that regulates the expression of genes involved in immune and inflammatory responses.

LCEPEEN Extract is orally active. The mechanisms by which it produces its effect in vivo have not yet been characterized in detail. The activation of NF-κB is mediated in part via Toll-like receptors. Due to their high molecular weight, the polysaccharides believed to be responsible for LCEPEEN Extract’s immunomodulatory effects are not expected to enter the circulation. Therefore, LCEPEEN Extract’s most likely site of action is the mucosal immune system. The intestinal mucosa is rich in lymphoid follicles and harbors numerous aggregates of lymphoid tissues in the form of Peyer’s patches. These specialized sites in the gut epithelium contain macrophages and dendritic cells, CD4+ and CD8+ lymphocytes and naive B cells. Activated immune cells can exit Peyer’s patches and enter the systemic circulation. Cells isolated from Peyer’s patches of mice treated with LCEPEEN Extract show an increased IL-6 and IgA production confirming that the intestinal mucosa is a site at which LCEPEEN Extract produces its effect. Cells isolated from spleens of mice fed an LCEPEEN Extract diet also show changes in their functional activity as reflected in an increased production of interferon-γ. This observation demonstrates that LCEPEEN Extract has an effect on immune cells in secondary lymphoid organ.

No toxic effects have been observed in cell culture or in laboratory animals. LCEPEEN Extract is safe in humans even when ingested in large amounts for extended periods of time. It has been used by many patients for nearly two years. It has efficacy at low doses after oral administration, and it is well tolerated. Clinical data collected so far show that LCEPEEN Extract provides an impressive range of health benefits in patients. It shortens the duration of infections, shows anti-viral activity in patients with herpes simplex-2 and HIV, reduces pain and strain, ameliorates swelling of inflamed joints and tissues, and accelerates wound healing. This broad range of health promoting effects distinguishes LCEPEEN Extract from other immunostimulants used clinically. The positive effect of LCEPEEN Extract on inflammatory pain and swelling of inflamed joints and tissues is a property not typically associated with immunostimulants. The biological and molecular mechanisms underlying these effects remain to be characterized. The clinical observations suggest that LCEPEEN Extract not only stimulates mechanisms involved in the initiation of inflammatory responses but can also modulate mechanisms involved in the resolution of inflammation. This unusual pharmacological profile suggests that LCEPEEN Extract has a positive effect on the overall response of the innate and adaptive immune system to foreign pathogens.

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Please notice! The presented product is a dietary supplement and this presentation does not intend to attribute to it the property of preventing, treating or curing any human disease, or does not refer to such properties. Exact to Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002